What do near-death experiences and psychedelic experiences have in common?

Researchers analysed the similarities and differences between a near-death experience and the experience induced by a psychedelic drug.

What interferes the most with our short-term memory?

Researchers performed experiments to explore the effects of changing-state vibrotactile sequences on short-term memory.

Can childhood trauma cause insomnia in adults?

Research has shown that adverse childhood experiences result in more dysfunctional ways of shame coping and increase the severity of insomnia in adulthood.

Effects of a web-based mindfulness intervention

In the scope of the research project 104/18 - Effect of mindfulness on EEG brain activity for cognitive and psychological well-being in the elderly, led by Samantha Galluzzi, the research team aimed to assess both short and long-term cognitive, psychological, and physiological outcomes of an adapted 8-week mindfulness-based intervention (MBI) delivered through live web-based videoconferencing among a group of healthy older adults. The findings, published in BMC Geriatrics, in the article Cognitive, psychological, and physiological effects of a web-based mindfulness intervention in older adults during the COVID-19 pandemic: an open study indicate that participants improved in various domains, including verbal memory, attention switching and executive functions, interoceptive awareness, and rumination both pre-to-post MBI and at 6-month follow-up (T6). Notably, the most significant changes, with medium effect sizes, were observed in immediate verbal memory and self-regulation in interoceptive awareness, and these improvements were sustained at T6. Furthermore, the study revealed changes in EEG alpha1 and alpha2 activity modulation, which correlated with improvements in attention switching, executive function and rumination.

Does autosuggestion modulate our reality?

Autosuggestion posits that individuals can influence their own mental and physiological states through the repetition of a thought, a so-called suggestion. The research team led by Elena Azañón tested whether autosuggestion can alter participants’ somatosensory perception at the finger. In three separate experiments, participants were asked to modulate the perceived intensity of vibrotactile stimuli at the fingertip through the inner reiteration of the thought that this perception feels very strong (Experiment 1, n = 19) or very weak (Experiments 2, n = 38, and 3, n = 20), while they were asked to report the perceived frequency. Notably, an increase in the intensity of vibrotactile stimuli, keeping the frequency constant, can lead either to an increase or a decrease in its perceived frequency. Whereas the direction of this effect is different between people, it is usually constant within one individual and can therefore be used to test for the effect of autosuggestion in a within-subject design. It was observed that the task to change the perceived intensity of a tactile stimulus via the inner reiteration of a thought modulates tactile frequency perception. This study was conducted in the scope of the research project 296/18 - The power of mind: Altering cutaneous sensations by autosuggestion, supported by the BIAL Foundation, and published in the paper How the inner repetition of a desired perception changes actual tactile perception in the journal Scientific Reports.

Inter-individual differences in fear extinction

In the scope of the research project 85/18 - Role of NT3/TrkC in the regulation of fear, supported by the BIAL Foundation, Mónica Santos and colleagues, using a behavioural model of fear extinction, assessed mice that successfully extinguish fear and those that fail. Inter-individual differences in the ability to extinguish fear have a dual outcome: first on setting the vulnerability to develop anxiety and fear-related disorders, and second on determining the effectiveness of exposure therapy towards patients in this group of disorders. Indeed, fear extinction mechanisms that support exposure therapy principles are often impaired in patients with fear-related disorders. The formation of fear memories and their extinction is dependent on synaptic plasticity events occurring at amygdalar fear and extinction microcircuits. Using the aforesaid model, the team identified a key role for the NT3-TrkC system in fear extinction, through modulation of amygdalar NMDAR composition and synaptic plasticity. This study validates the TrkC pathway as a potential therapeutic target for individuals with fear-related disorders and reveals that combining exposure therapies with drugs that enhance synaptic plasticity may represent a more effective and lasting way of treating anxiety disorders. To know more read the paper The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity published in the journal Molecular Psychiatry.